The closure will start from 10pm on April 8 to 5am on April 9 on the M25 westbound, from junction four to Hewitts Roundabout.
Hewitts Roundabout and M25 Junction four are linked by a 1.2kilometre motorway spur.
The disruption is for coring works.
Drivers can expect slight delays of under ten minutes.
The closure was announced on the latest works list from National Highways.
The list only covers motorways and major A-roads so smaller roads are not included in the schedule.
