The A27 has been closed since the early hours of this morning following the collision. Read live updates here.
A spokeswoman for Sussex Police said: “Emergency services were called to a report of a serious collision involving a single vehicle on the A27 westbound near the Amex stadium at Falmer at 2am on Wednesday (28 January).
“One man was sadly declared deceased at the scene, his next of kin have been informed and our thoughts are with his family during this time.
“A 16-year-old boy has been taken to hospital to be treated for injuries.
“No arrests have been made.
“The road closure on the A27 has been extended and is now in place on the westbound carriageway of the A27 between the Kingston roundabout and the Carden Avenue, Brighton junction.
“We advise motorists to plan alternative routes to avoid the area.”
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