Scientists at the University of Adelaide’s Davies Livestock Research Centre (DLRC) have unveiled the most comprehensive cattle genome ever assembled, a breakthrough expected to improve Wagyu breeding and enhance beef marbling. The research delivers a clearer picture of cattle genetics than any previous reference.
“We have presented a near complete cattle genome that is 16 percent longer than the current reference genome,” said Dr. Lloyd Low, a senior author of the study and researcher at the DLRC. The findings were published in Nature Communications.
“This new Wagyu genome provides a much more complete and accurate view of the genetic blueprint behind one of the world’s most prized beef breeds,” said study co-lead author Paulene Pineda from the University of Adelaide.
Unlocking the Genetics of Beef Quality and Profit
Beyond scientific insight, the discovery carries clear economic potential for the beef industry. By revealing more of the Wagyu genetic makeup, researchers have created a powerful tool for identifying traits that influence quality and profitability.
“The Wagyu genome provides a foundational genetic resource to identify variants responsible for marbling and other traits affecting profit,” said Professor Wayne Pitchford, Director of the University of Adelaide’s Davies Livestock Research Centre and a co-author of the study.
Using the new genome, the team identified hundreds of previously unknown genes and uncovered far more structural genetic variants than earlier reference genomes allowed.
“These structural variants are an untapped genetic resource and some of them may be key to some of the prized traits of cattle. Moreover, they highlight the hidden diversity present within a seemingly homogeneous breed,” said Dr. Callum MacPhillamy, a co-lead author from CSIRO.
Benefits Extend Beyond Wagyu
Researchers say the impact of this work goes well beyond Wagyu cattle. The improved genome offers breeders across the industry a more precise way to select animals for desirable traits.
Associate Professor Cynthia Bottema, a co-author of the study from the DLRC, said the advance gives breeders greater control over outcomes.
“Our new cattle genome means breeders now have a better tool that will allow for greater precision when identifying and selecting for traits like marbling, fertility and disease resistance — not only in Wagyu, but other cattle breeds as well,” she said.
The findings arrive at a time when Australia’s beef sector continues to grow. Beef production reached 706,296 tonnes in the quarter ending June 2025, while the gross value of cattle and calves slaughtered totaled $4.9 billion. Recent export data shows the industry is now worth more than $1 billion.
International Collaboration and Future Goals
The study was conducted in collaboration with the United States Department for Agriculture (USDA), building on a long-standing research partnership with the University of Adelaide.
“Work completed jointly by the University of Adelaide and the USDA has led to the assembly of some of the world’s most complete livestock genomes,” Dr. Low said.
“Together, we pioneered the trio binning method for genome assembly. This approach was also published in Nature Communications.”
While the new genome offers unprecedented detail, researchers say there is still more work ahead.
“In this study, we successfully assembled the first complete cattle X chromosome and four autosomes. However, assembling the remaining chromosomes to the same level of completeness remains an aim for future work,” Dr. Low said.
“Our next goal is to combine the Wagyu assembly with other high-quality cattle genomes to build a pangenome graph that better represents the full spectrum of genetic diversity in the species.”
