A semi-detached house in Rymill Road, St Leonards, was cordoned off after a man was taken to hospital with serious injuries.
Sussex Police went to the property in response to a report of serious assault at around 5.39pm on Monday.
Police have arrested a man and a woman on suspicion of attempted murder.
“The public can expect to see an increased police presence in the area as our enquiries continue.
“Anyone with any information is asked to report it online or call 101, quoting serial 991 of 11/11.”
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