The work will affect trains on Saturday (October 26) and Sunday (October 27).
We have compiled all of the details on these works so that you can plan your journey this weekend.
Sunday (October 27):
Engineering work is taking place at Lewisham on Sunday, closing all lines through the station and through Bexleyheath.
No services will call at Lewisham.
Services between London Victoria and Dartford will not run.
Services between London Cannon Street and Slade Green via Bexleyheath will be diverted to run via Sidcup.
Services between London Charing Cross and Hayes will not call at Lewisham.
Services between London Charing Cross and Sevenoaks will not call at Lewisham.
Replacement buses will run between New Cross and Dartford via Bexleyheath, calling at all stations.
Passengers can use alternative services at no extra charge.
These include Docklands Light Railway between Lewisham and Greenwich.
Other services include the P12 and 78 between Peckham Rye and Nunhead, 484 between Denmark Hill and Lewisham, the 21, 225, and 273 between Hither Green, Lewisham and New Cross, and the P4, 284, and 122 between Lewisham and Ladywell.
Sunday (October 27):
Engineering work is taking place at London Victoria, closing some lines.
Trains from London Victoria to Ramsgate and Dover Priory will now run from London Cannon Street to Gillingham and Sittingbourne.
They will not stop at any stations between London Bridge and St Mary Cray or Swanley.
Trains from London Victoria to Ashford International via Maidstone East will now run from London Cannon Street instead of London Victoria and will not stop at any stations between London Bridge and St Mary Cray.
Trains from London Victoria to Orpington will now run from London Blackfriars instead of London Victoria and will also stop at Elephant & Castle.
Brixton station will be closed all day.
Trains from London Victoria to Dartford via Bexleyheath will not run.
Saturday and Sunday (October 26 and October 27):
Engineering work is taking place between Sittingbourne and Faversham / Dover Priory, closing some lines.
As a result, services between London Victoria and Ramsgate / Dover Priory via Chatham will only run between London Victoria and Sittingbourne.
Additional train services will operate between Faversham and Ramsgate or Dover Priory.
Services between London St Pancras International and Ramsgate via Faversham will run between London St Pancras International and Sittingbourne only.
Services between Sittingbourne and Sheerness-on-Sea will not run because of further engineering work.
Replacement bus services will run direct between Sittingbourne and Sheerness-on-Sea, and another service calling at Teynham.
On Sunday, engineering work will be extended to Herne Bay and Dover Priory.
Services between London Victoria and Ramsgate via Chatham or Dover Priory via Denmark Hill will instead operate between London Cannon Street and Gillingham or Sittingbourne.
Additional train services will operate between Herne Bay and Ramsgate.
Services between London St Pancras International and Ramsgate via Faversham will run between London St Pancras International and Sittingbourne.
Services between Sittingbourne and Sheerness-on-Sea will not run due to further engineering work.
Replacement buses will run between Sittingbourne and Herne Bay, calling at all stations except Teynham.
Buses will also run through Sittingbourne and Canterbury East, calling at Faversham only, as well as Sittingbourne and Selling, calling at all stations.
On Sunday, due to a local road closure, buses are unable to call at Shepherds Well and Snowdown.
