Emergency services swarmed the area after reports of two men injured within the Burnbank Centre at around 3.50pm.
A 36-year-old man was then pronounced dead at the scene.
A 59-year-old man was taken by ambulance to the Queen Elizabeth University Hospital in Glasgow.
Police remain on the scene. https://t.co/YMO9a3995L pic.twitter.com/YVzW4CJd4R
— Glasgow Times (@Glasgow_Times) October 21, 2024
Police have not confirmed how the men were injured at this stage.
Officers remain on the scene and have locked down the area near Ann Street this evening.
A large cordon has sealed off the area while investigations continue.
One person said: “It all kicked off and suddenly police arrived everywhere.
“It is really scary, we can’t go anywhere near the area.
“Someone has died, we are all really worried.”
A Police Scotland spokesperson said: “Around 3.50pm on Monday, 21 October, 2024, we received a report of two men injured within the Burnbank Centre, Hamilton.
“Emergency services attended and a 36-year-old man was pronounced dead at the scene.
“A 59-year-old man was taken by ambulance to the Queen Elizabeth University Hospital in Glasgow.
“Enquiries are ongoing to establish the exact circumstances of the incident.”