A van and a lorry were involved in a crash this morning at 7.10am on the A264 Five Oaks Road near Horsham.
The road remains closed in both directions.
READ MORE: Live: A264 closed near Horsham after lorry crash
South East Coast Ambulance Service (Secamb) crews attended the scene at 7.15am alongside a team from Kent Surrey Sussex Air Ambulance by road.
One person was assessed and treated at the scene before being taken in a serious condition to Royal Sussex County Hospital in Brighton, Secamb said.
A spokesman for Sussex Police said: “Anyone who witnessed the incident or has any information or dashcam footage is asked to contact police online or call 101 quoting Operation Cureen.”
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