Two children and another man were also hurt in the smash on the A267 North Street in Horam, near Hailsham.
The incident happened at around 3.40pm yesterday.
READ MORE: Man, 34, killed in crash
A spokesman for Sussex Police said this afternoon: “A man was taken to hospital with serious injuries, where he remains.
“Another man and two children involved in the collision suffered minor injuries.
“Witnesses or anyone with any information is asked to contact police online or call 101 quoting serial 791 of 14/06.”
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