Emergency services responded to a collision involving two cars at the junction of the A259 and A27 in Pevensey at around 12.30pm today.
An air ambulance attended and multiple fire engines.
Read more: Updates as crash closes A27- air ambulance on scene
An elderly woman has been taken to hospital with serious injuries.
Two people were treated at the scene for minor injuries.
All lanes have been re-opened following the two-hour closure.
Any witnesses or anyone who has dash-cam footage is asked to report online or call 101 quoting 515 of 07/12.
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