The discovery was made after officers executed a warrant at a premises on Melford Road on Thursday, December 11.
They found cocaine with an estimated street value of more than £8m, making it one of the largest drugs recoveries in Scotland.
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Three men, aged 29, 46 and 65, have been arrested and charged in connection with the find.
They are due to appear at Hamilton Sheriff Court on Monday, December 15.
An investigation into the full circumstances remains ongoing.
Detective Superintendent Steven Elliot said: “This was a sizeable recovery – one of the most significant we’ve seen in Scotland.
“This work underlines our commitment to the Serious Organised Crime Taskforce and the country’s Serious Organised Crime Strategy.
“Taking drugs off the street is a priority for Police Scotland.
“Drugs cause misery in our communities, and the public has a vital role in helping us to trace those involved in the supply of illegal substances.
“Anyone with information or concerns about drugs should contact us via 101 or make a call to Crimestoppers on 0800 555 111.”
