Police were called to Western Road, Brighton, at around 2.30am yesterday, July 5.
Two groups of men were reported to be fighting.
The fight is believed to have started outside Buddha Nail Studio before continuing westbound opposite McDonald’s.
One group fled the scene towards Churchill Square.
A man in his 30s was treated at the scene by the ambulance service and taken to hospital, where he remains in a serious condition.
Detective Inspector Ed Neve said: “This was a serious assault that has left a man with significant injuries.
“We know there were a number of people involved and multiple witnesses in such a central location, so we are asking anyone with information or relevant video footage to contact us online or via 101, quoting Operation Axle.”
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