London Road, between Braidfauld Street and Maukinfauld Road, will be shut to traffic in both directions.
The closure will take place from 8am to 6pm on Saturday, April 5, and for the full day and overnight on April 6 and April 7.
The road will also be closed from 8am to 6pm on Tuesday, April 8.
Diversions will be in place via Braidfauld Street, Tollcross Road, Gallowgate, Clyde Gateway and London Road.
