The Avenue in Bevendean, Brighton, was closed earlier today at around 2.30pm by police.
Multiple ambulance vehicles were parked in The Avenue as they dealt with an incident.
A cordon was also set up at the scene.
An air ambulance was also pictured on a nearby green.
One eyewitness described traffic as “gridlocked” in the surrounding area.
Sussex Police confirmed the collision involved the driver of a moped travelling north and a cyclist.
The cyclist, a 66-year-old man, sustained life-threatening injuries and was taken to hospital.
The force is appealing for witnesses.
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