Network Rail will replace the railway bridge over East Kilbride Road at Busby station in March.
It will be installed between Monday, March 17 and Friday, March 28.
The new structure will be stronger and more resilient than the previous bridge reducing the risk of damage to the railway if struck by high-sided vehicles using the road below.
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The project will see the existing steel structure replaced with a steel and reinforced concrete one and has been timed to take place during the ongoing closure of the East Kilbride line.
The allow the works to take place, East Kilbride Road (A727) at Busby station will be closed during the following times;
- From 11pm to 6am from March 17 to 21 with contrafow in place during the day
- It will be fully closed from March 21 to 25
- From 11pm to 6am from March 25 to 28 with contraflow in place during the day
A diversion will be in place during the road closures while contraflow will involve having temporary traffic lights in place.
Motorists are advised to allow for extra time on their journeys.
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Paul Reilly, Network Rail’s senior programme manager, said: “We know there’s never a great time to close a busy road, but replacing the bridge at Busby station alongside the current East Kilbride Enhancement project will avoid the need for a separate closure in the future.
“By doing this, we’ll complete the job faster and more efficiently.
“We thank our neighbours for their patience during the project.”
Busby station is currently closed until May 18 with a replacement bus service operating.
During the bridge works, the last replacement bus to Busby departs Glasgow Central station at 9.49pm and from East Kilbride station at 10.28pm.
During the full closure, a minibus will run between Busby and Clarkson, with an additional local minibus in Busby, to keep the community connected.
You can find out more at scotrail.co.uk/east-kilbride-enhancement-project.