Approved peanut allergy therapeutics typically address patients with low allergen thresholds, but nearly half of people with peanut allergies have higher thresholds and may be easily treatable, according to research. In this phase 2 trial, participants ranging from age 4 to 14 years old, reacting to cumulative peanut doses of 443-5043 mg, were randomized into an avoidance group and a peanut oral immunotherapy (POIT) group to evaluate respondence to an approximately 3400 mg maintenance dose of store-purchased, home-measured peanut products. During the study, 73 participants fulfilled the entry criteria and 38 were randomized to the POIT. Afterwards, in an oral challenge (OFC), participants were given up to 9,043 mg of peanut protein. For those on POIT tolerating 9,043 mg, researchers undertook another OFC for sustained unresponsiveness (SU) that was determined after 16 weeks of ad-libitum ingestion before 8 weeks of peanut avoidance.
The research, funded by the NIAID, showed 100% success for peanut desensitization in the POIT group compared to only 21.0% for the peanut avoidance group. The results also found that 100% of the group treated with POIT tolerated 9,043 mg in the oral food challenge while only 10% of the avoidance group tolerated the same amount. Additionally, 86.7% of the POIT group continued to tolerate 9,043 mg on sustained unresponsiveness evaluation and by intention-to-treat, and 68.4% on POIT achieved sustained unresponsiveness/natural tolerance of 9,043 mg compared to 8.6% who continued avoiding.
Visit aaaai.org to learn more about peanut allergies. Research presented at the 2025 AAAAI / WAO Joint Congress, February 28 – March 3 in San Diego, CA, is published in an online supplement to The Journal of Allergy and Clinical Immunology (JACI).
The American Academy of Allergy, Asthma & Immunology (AAAAI) is the leading membership organization of more than 7,100 allergists, asthma specialists, clinical immunologists and other professionals with a special interest in the research and treatment of allergic and immunologic diseases. Established in 1943, the AAAAI is the go-to resource for patients living with allergies, asthma and immune deficiency disorders.
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SOURCE The American Academy of Allergy, Asthma & Immunology
