The crossing, which connects Dartford in Kent to Thurrock in Essex via the A282, is a key link over the River Thames.
According to the National Highways website, no closures are scheduled from Friday morning (December 20) to Sunday, December 22.
This comes as high streets, shopping centres, and retail parks experience a surge in visitors rushing to buy last-minute gifts and festive supplies.
Families traveling home for the holidays or heading on pre-Christmas getaways will benefit from smoother journeys, with the absence of delays helping to ease congestion and improve travel times.
The timing is especially welcomed after overnight closures of the northbound West Tunnel last week for maintenance, which ran from Monday, December 16, to Friday, December 20.
This information is accurate at the time of publication but could change due to adverse weather.
Details of planned closures for January 2025 have not yet been released.