The impact on traffic is expected to be minimal, with delays anticipated to be less than 10 minutes.
The affected section runs from junction four to Hewitts Roundabout, where a lane closure will be in place to allow for horticultural works.
Horticulture is the practice of cultivating and managing plants.
The closure is as follows:
From 10pm on October 1 to 5am on October 3, motorists can expect slight delays of less than 10 minutes on the M25 westbound.
National Highways is responsible for maintaining motorways and major A-roads, so closures of smaller roads will not be included in their schedule.