The presenter, who is from Cuckfield, near Haywards Heath, revealed he has been diagnosed with stage one laryngeal cancer.
Jamie, 53, presents the station’s weekly breakfast show alongside Amanda Holden.
In a statement on social media, he said: “Hi folks, as you know – I recently had an operation to remove a lesion from my vocal cords.
“The biopsy has identified this as stage 1 laryngeal cancer. So – I have cancer – but cancer doesn’t have me.
“The prognosis is very positive and I’m hoping to be back with you in October.
“Until then, I’ve been told to give my voice a rest and leave you in the mostly capable hands of JK (Jason King) and Amanda.
“Big thanks to them and all the Global family who have been unbelievably supportive.
“Be thankful for this day, and when I next see you, I’ve got a great story to tell … Jamie x.”
Jamie found fame in the late 1990s, co-hosting Top Of The Pops and BBC children’s series Live And Kicking alongside Zoe Ball.
He has also presented game shows The Games for Channel 4 and Britain’s Best Brain for Channel 5.
He married Sophie Siegle in Ditchling, where he was then living, in 2007 and the couple have two children.
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On the Heart Breakfast show this morning Amanda Holden told listeners: “It feels only right that we get you completely up to speed with what’s going on.
“As you might have seen on Jamie’s socials, he recently had an operation to remove a lesion from his vocal cords.
“And we wanted to let you know that this biopsy has actually been identified as stage one laryngeal cancer.
“Now, even though it’s been identified as cancer, it is not all bad news.
“We are going to do him proud, him and Sophie and the boys, they’re listening at home.
“And I know that after this announcement, all of you listening as well, are going to be sending your best wishes to our king, our lovely Jamie, who is going to be better and back with us very soon.”
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