Officers remain on scene, with Henderson Drive closed between the junctions with Marsh Street and Cavell Crescent.
Kent Police were first called at 6.50am on Saturday to reports of a disturbance at a property.
Officers attended with colleagues from South East Coast Ambulance Service and a woman was pronounced dead at the scene after being found with injuries consistent with a stabbing, police said.
A man in his 20s, who was known to the victim, was arrested on suspicion of murder and taken into custody.
Anyone who has any information is urged to call Kent Police on 01474 366149 quoting reference 17-0284.
Jim Dickson MP for Dartford said on X: “My thoughts are with the victim and all those affected by this morning’s tragic incident in Temple Hill.
“I’d like to thank the police for their swift response & encourage anyone with relevant information to contact them.”
