Glasgow City Council has said Cathcart Road will be shut at its junction with Allison Street on Sunday, June 9, between 8am and 6pm.
It will also be closed on Monday, June 10, and Tuesday, June 11, from 9.30am until 3.30pm each day.
The local authority said the closure is in place to allow essential carriageway resurfacing works.
Drivers are being urged to expect delays and use an alternative route if possible.