Motorists could face hold-ups lasting between 10 and 30 minutes.
National Highways maintains motorways and major A-roads, so smaller road shutdowns are not on the schedule.
Here is the list of closures – with some already in place and some upcoming.
• A282, from 10pm May 1 to 5.30am June 1, slight delays (under 10 minutes): A282 northbound, Dartford Crossing West Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm May 4 to 5am May 5, slight delays (under 10 minutes): A282 northbound, Dartford Crossing West Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm May 5 to 5am May 6, slight delays (under 10 minutes): A282 northbound, Dartford Crossing East Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm May 7 to 5am May 10, slight delays (under 10 minutes): A282 northbound, Dartford Crossing East Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm May 7 to 5.30am May 10, slight delays (under 10 minutes): M25 clockwise, junction 1A, Lane closures for electrical works.
• M25, from 10pm May 7 to 5am May 8, slight delays (under 10 minutes): M25 Anticlockwise, junction 3 to junction 2, Lane closures for electrical works.
• A2, from 10pm May 9 to 6am May 10, moderate delays (10-30 minutes): A2 eastbound, M25 to Bean interchange, Lane closures for technology work.
• A2, from 8pm May 10 to 6am May 11, slight delays (under 10 minutes): A2 eastbound, Bean to Pepperhill, lane closure for signage work.
• A282, from 11pm May 10 to 5.30am May 11, slight delays (under 10 minutes): M25 Anticlockwise, junction 1B to junction 1A, Lane and slip road closure for sign works, diversion via National Highways network.
• A282, from 10pm May 13 to 5.30am May 15, slight delays (under 10 minutes): M25, junction 1A Roundabout, Lane closures for electrical works.