The car park at Uddingston station will be closed from midnight (12.01am on Thursday, March 21) until 11.59pm on Sunday, March 24.
Drivers are urged to make sure they have removed their car from the car park before midnight.
We reported that the closure will allow engineers to safely crane 75 tonnes of steel to build a new footbridge and lift tower.
It is part of the Access for All programme to improve accessibility at stations across railway stations in Scotland.
A pedestrian walking route will remain available throughout the closure and all temporary changes will be signposted well in advance and during the closure of the works.