Layla McKee was last seen around 9pm on Saturday, March 9, at a bus stop on Righead Industrial Estate in Bellshill.
The 13-year-old is described as being 5ft 4inch tall, slim build, and has fair/blonde hair.
She was last seen wearing a black puffer jacket, black leggings, and black and white shoes.
A spokesperson for Police Scotland said: “Anyone who has information on Layla’s whereabouts is asked to contact police on 101 quoting incident 3448 of March 9, 2024.”