Philipshill Road will be shut between Mill Cottage and The National Museum of Rural Life from Friday, February 16 until Sunday, March 31.
The road will be closed to allow emergency Scottish Water works to take place in the area.
A diversion will be in place for drivers.
A spokesperson for South Lanarkshire Council said: “Whilst this order remains in force no person shall park, drive or cause or permit to be driven any motor vehicle on the sections of road specified by reason of emergency Scottish Water works.”
